Kohanim and Wine

 The subject of drinking wine is very appropriate this time of year. One of the 613 Mitzvot is that it is forbidden for a Kohen to enter the Beit Hamikdash in an intoxicated state.

The Rambam discusses this idea and says that Kohanim must keep in mind that the Beit Hamikdash could be rebuilt at any time and he might be needed to serve tomorrow. If he wakes up with a hangover, he also cannot serve. Therefore, Kohanim in particular should be careful never to be drunk.

The של״ה הקודש as well as the Rambam were strongly against any Jew getting drunk. This included Purim where they felt that some wine should be drunk just to raise the spirits and feel the joy of the day.