This week's Parsha, לך לך speaks of the Mitzva of ברית מילה. The של״ה הקודש says that there is a connection between circumcision and inheriting the land. From the Kabbala, the foreskin represents the impurity of the sin of the serpent. Removing the foreskin means removing the קליפה, or shell, that might have prevented holiness from entering. We cannot lay claim to the land if such impurity exists on our bodies. With מילה, our 248 limbs are whole. When Yitzchak died, Eisav's descendants stopped performing circumcision. The מילה is a clear sign of the special connection between Hashem and עם ישראל. This is why the nations of the world have continuously tried to prevent Jews from performing this Mitzva.